2.2.61.1.10

Methods for determining oral and dermal toxicity of mixtures

When classifying and assigning the appropriate packing group to mixtures in Class 6.1 in accordance

with the oral and dermal toxicity criteria (see 2.2.61.1.3), it is necessary to determine the acute LD50

of the mixture.

2.2.61.1.10.1

If a mixture contains only one active substance, and the LD50 of that constituent is known, in the

absence of reliable acute oral and dermal toxicity data on the actual mixture to be carried, the oral or

dermal LD50 may be obtained by the following method:

2.2.61.1.10.2

If a mixture contains more than one active constituent, there are three possible approaches that may be

used to determine the oral or dermal LD50 of the mixture. The preferred method is to obtain reliable

acute oral and dermal toxicity data on the actual mixture to be carried. If reliable, accurate data are not

available, then either of the following methods may be performed:

(a) Classify the formulation according to the most hazardous constituent of the mixture as if that

constituent were present in the same concentration as the total concentration of all active

constituents; or

(b) Apply the formula:

where:

C = the percentage concentration of constituent A, B, ..., Z in the mixture;

T = the oral LD50 values of constituent A, B, ... Z;

TM = the oral LD50 value of the mixture.

NOTE: This formula can also be used for dermal toxicities provided that this information is

available on the same species for all constituents. The use of this formula does not take into

account any potentiation or protective phenomena.

2.2.61.1.11

Classification of pesticides

All active pesticide substances and their preparations for which the LC50 and/or LD50 values are

known and which are classified in Class 6.1 shall be classified under appropriate packing groups in

accordance with the criteria given in 2.2.61.1.6 to 2.2.61.1.9. Substances and preparations which are

characterized by subsidiary risks shall be classified according to the precedence of hazard Table in

2.1.3.10 with the assignment of appropriate packing groups.

2.2.61.1.11.1

If the oral or dermal LD50 value for a pesticide preparation is not known, but the LD50 value of its

active substance(s) is known, the LD50 value for the preparation may be obtained by applying the

procedures in 2.2.61.1.10.

NOTE: LD50 toxicity data for a number of common pesticides may be obtained from the most current

edition of the document "The WHO Recommended Classification of Pesticides by Hazard and

Guidelines to Classification" available from the International Programme on Chemical Safety, World

Health Organisation (WHO), 1211 Geneva 27, Switzerland. While that document may be used as a

source of LD50 data for pesticides, its classification system shall not be used for purposes of transport

classification of, or assignment of packing groups to, pesticides, which shall be in accordance with

the requirements of ADR.

2.2.61.1.11.2

The proper shipping name used in the carriage of the pesticide shall be selected on the basis of the

active ingredient, of the physical state of the pesticide and any subsidiary risks it may exhibit (see

3.1.2).

2.2.61.1.12

If substances of Class 6.1, as a result of admixtures, come into categories of risk different from those

to which the substances mentioned by name in Table A of Chapter 3.2 belong, these mixtures or

solutions shall be assigned to the entries to which they belong on the basis of their actual degree of

danger.

NOTE: For the classification of solutions and mixtures (such as preparations and wastes), see

also 2.1.3.

2.2.61.1.13

On the basis of the criteria of 2.2.61.1.6 to 2.2.61.1.11, it may also be determined whether the nature

of a solution or mixture mentioned by name or containing a substance mentioned by name is such that

the solution or mixture is not subject to the requirements for this Class.

2.2.61.1.14

Substances, solutions and mixtures, with the exception of substances and preparations used as

pesticides, which are not classified as acute toxic category 1, 2 or 3 according to Regulation (EC) No

1272/20083, may be considered as substances not belonging to class 6.1.

2.2.61.2

Substances not accepted for carriage

2.2.61.2.1

Chemically unstable substances of Class 6.1 shall not be accepted for carriage unless the necessary

precautions have been taken to prevent the possibility of a dangerous decomposition or

polymerization under normal conditions of carriage. For the precautions necessary to prevent

polymerization, see special provision 386 of Chapter 3.3. To this end particular care shall be taken to

ensure that receptacles and tanks do not contain any substances liable to promote these reactions.

2.2.61.2.2

The following substances and mixtures shall not be accepted for carriage:

- Hydrogen cyanide, anhydrous or in solution, which do not meet the descriptions of

UN Nos. 1051, 1613, 1614 and 3294;

- metal carbonyls, having a flash-point below 23 °C, other than UN Nos. 1259 NICKEL

CARBONYL and 1994 IRON PENTACARBONYL;

- 2,3,7,8-TETRACHLORODIBENZO-P-DIOXINE (TCDD) in concentrations considered

highly toxic in accordance with the criteria in 2.2.61.1.7;

- UN No. 2249 DICHLORODIMETHYL ETHER, SYMMETRICAL;

- Preparations of phosphides without additives inhibiting the emission of toxic flammable gases.

2.2.61.3

List of collective entries

Toxic substances without subsidiary risk(s)

a Substances and preparations containing alkaloids or nicotine used as pesticides shall be classified under UN

No. 2588 PESTICIDES, SOLID, TOXIC, N.O.S., UN No. 2902 PESTICIDES, LIQUID, TOXIC, N.O.S. or UN No. 2903

PESTICIDES, LIQUID, TOXIC, FLAMMABLE, N.O.S.

b Active substances and triturations or mixtures of substances intended for laboratories and experiments and for

the manufacture of pharmaceutical products with other substances shall be classified according to their toxicity (see

2.2.61.1.7 to 2.2.61.1.11).

c Self-heating substances, slightly toxic and spontaneously combustible organometallic compounds, are

substances of Class 4.2.

d Water-reactive substances, slightly toxic, and water-reactive organometallic compounds, are substances of

Class 4.3.

e Mercury fulminate, wetted with not less than 20% water, or mixture of alcohol and water by mass is a substance

of Class 1, UN No. 0135.

f Ferricyanides, ferrocyanides, alkaline thiocyanates and ammonium thiocyanates are not subject to the

provisions of ADR.

g Lead salts and lead pigments which, when mixed in a ratio of 1:1,000 with 0.07M hydrochloric acid and stirred

for one hour at a temperature of 23 °C ± 2 °C, exhibit a solubility of 5% or less, are not subject to the provisions

of ADR.

h Articles impregnated with this pesticide, such as fibreboard plates, paper strips, cotton-wool balls, sheets of

plastics material, in hermetically closed wrappings, are not subject to the provisions of ADR.

h Articles impregnated with this pesticide, such as fibreboard plates, paper strips, cotton-wool balls, sheets of

plastics material, in hermetically closed wrappings, are not subject to the provisions of ADR.

i Mixtures of solids which are not subject to the provisions of ADR and of toxic liquids may be carried under UN

No. 3243 without first applying the classification criteria of Class 6.1, provided there is no free liquid visible at the time

the substance is loaded or at the time the packaging, container or transport unit is closed. Each packaging shall

correspond to a design type that has passed a leakproofness test at the packing group II level. This entry shall not be

used for solids containing a packing group I liquid.

j Highly toxic and toxic flammable liquids having a flash-point below 23 °C are substances of Class 3 except

those which are highly toxic by inhalation, as defined in 2.2.61.1.4 to 2.2.61.1.9. Liquids which are highly toxic by

inhalation are indicated as "toxic by inhalation" in their proper shipping name in Column (2) or by special provision

354 in Column (6) of Table A of Chapter 3.2.

k Flammable liquids, slightly toxic, with the exception of substances and preparations used as pesticides, having a

flash-point between 23 °C and 60 °C inclusive, are substances of Class 3.