The following substances and mixtures shall not be accepted for carriage:
- Hydrogen cyanide, anhydrous or in solution, which do not meet the descriptions of
UN Nos. 1051, 1613, 1614 and 3294;
- metal carbonyls, having a flash-point below 23 °C, other than UN Nos. 1259 NICKEL
CARBONYL and 1994 IRON PENTACARBONYL;
- 2,3,7,8-TETRACHLORODIBENZO-P-DIOXINE (TCDD) in concentrations considered
highly toxic in accordance with the criteria in 2.2.61.1.7;
- UN No. 2249 DICHLORODIMETHYL ETHER, SYMMETRICAL;
- Preparations of phosphides without additives inhibiting the emission of toxic flammable gases.

List of collective entries

Toxic substances without subsidiary risk(s)

a Substances and preparations containing alkaloids or nicotine used as pesticides shall be classified under UN
No. 2588 PESTICIDES, SOLID, TOXIC, N.O.S., UN No. 2902 PESTICIDES, LIQUID, TOXIC, N.O.S. or UN No. 2903
PESTICIDES, LIQUID, TOXIC, FLAMMABLE, N.O.S.
b Active substances and triturations or mixtures of substances intended for laboratories and experiments and for
the manufacture of pharmaceutical products with other substances shall be classified according to their toxicity (see
2.2.61.1.7 to 2.2.61.1.11).
c Self-heating substances, slightly toxic and spontaneously combustible organometallic compounds, are
substances of Class 4.2.
d Water-reactive substances, slightly toxic, and water-reactive organometallic compounds, are substances of
Class 4.3.
 
e Mercury fulminate, wetted with not less than 20% water, or mixture of alcohol and water by mass is a substance
of Class 1, UN No. 0135.
f Ferricyanides, ferrocyanides, alkaline thiocyanates and ammonium thiocyanates are not subject to the
provisions of ADR.
g Lead salts and lead pigments which, when mixed in a ratio of 1:1,000 with 0.07M hydrochloric acid and stirred
for one hour at a temperature of 23 °C ± 2 °C, exhibit a solubility of 5% or less, are not subject to the provisions
of ADR.
h Articles impregnated with this pesticide, such as fibreboard plates, paper strips, cotton-wool balls, sheets of
plastics material, in hermetically closed wrappings, are not subject to the provisions of ADR.
 
 
h Articles impregnated with this pesticide, such as fibreboard plates, paper strips, cotton-wool balls, sheets of
plastics material, in hermetically closed wrappings, are not subject to the provisions of ADR.
i Mixtures of solids which are not subject to the provisions of ADR and of toxic liquids may be carried under UN
No. 3243 without first applying the classification criteria of Class 6.1, provided there is no free liquid visible at the time
the substance is loaded or at the time the packaging, container or transport unit is closed. Each packaging shall
correspond to a design type that has passed a leakproofness test at the packing group II level. This entry shall not be
used for solids containing a packing group I liquid.
j Highly toxic and toxic flammable liquids having a flash-point below 23 °C are substances of Class 3 except
those which are highly toxic by inhalation, as defined in 2.2.61.1.4 to 2.2.61.1.9. Liquids which are highly toxic by
inhalation are indicated as "toxic by inhalation" in their proper shipping name in Column (2) or by special provision
354 in Column (6) of Table A of Chapter 3.2.
k Flammable liquids, slightly toxic, with the exception of substances and preparations used as pesticides, having a
flash-point between 23 °C and 60 °C inclusive, are substances of Class 3.
 
 
c Self-heating substances, slightly toxic and spontaneously combustible organometallic compounds, are
substances of Class 4.2.
d Water-reactive substances, slightly toxic, and water-reactive organometallic compounds, are substances of
Class 4.3.
l Oxidizing substances, slightly toxic, are substances of Class 5.1.
m Substances slightly toxic and slightly corrosive, are substances of Class 8.
n Metal phosphides assigned to UN Nos. 1360, 1397, 1432, 1714, 2011 and 2013 are substances of Class 4.3.
 
 
m Substances slightly toxic and slightly corrosive, are substances of Class 8.
 
 
 

Class 6.2 Infectious substances

Criteria

The heading of Class 6.2 covers infectious substances. For the purposes of ADR, infectious
substances are substances which are known or are reasonably expected to contain pathogens.
Pathogens are defined as microorganisms (including bacteria, viruses, rickettsiae, parasites, fungi) and
other agents such as prions, which can cause disease in humans or animals.
NOTE 1: Genetically modified microorganisms and organisms, biological products, diagnostic
specimens and intentionally infected live animals shall be assigned to this Class if they meet the
conditions for this Class.
The carriage of unintentionally or naturally infected live animals is subject only to the relevant rules
and regulations of the respective countries of origin, transit and destination.
NOTE 2: Toxins from plant, animal or bacterial sources which do not contain any infectious
substances or organisms or which are not contained in them are substances of Class 6.1, UN Nos.
3172 or 3462.

Substances of Class 6.2 are subdivided as follows:
I1 Infectious substances affecting humans;
I2 Infectious substances affecting animals only;
I3 Clinical waste;
I4 Biological substances.

Definitions

For the purposes of ADR,
"Biological products" are those products derived from living organisms which are manufactured and
distributed in accordance with the requirements of appropriate national authorities, which may have
special licensing requirements, and are used either for prevention, treatment, or diagnosis of disease in
humans or animals, or for development, experimental or investigational purposes related thereto. They
include, but are not limited to, finished or unfinished products such as vaccines;
"Cultures" are the result of a process by which pathogens are intentionally propagated. This definition
does not include human or animal patient specimens as defined in this paragraph;
"Medical or clinical wastes" are wastes derived from the medical treatment of animals or humans or
from bio-research;
"Patient specimens" are human or animal materials, collected directly from humans or animals,
including, but not limited to, excreta, secreta, blood and its components, tissue and tissue fluid swabs,
and body parts being carried for purposes such as research, diagnosis, investigational activities,
disease treatment and prevention.

Classification

Infectious substances shall be classified in Class 6.2 and assigned to UN Nos. 2814, 2900, 3291 or
3373, as appropriate.

Infectious substances are divided into the following categories:

Category A: An infectious substance which is carried in a form that, when exposure to it occurs, is
capable of causing permanent disability, life-threatening or fatal disease in otherwise healthy humans
or animals. Indicative examples of substances that meet these criteria are given in the table in this
paragraph.
NOTE: An exposure occurs when an infectious substance is released outside of the protective
packaging, resulting in physical contact with humans or animals.
(a) Infectious substances meeting these criteria which cause disease in humans or both in humans
and animals shall be assigned to UN No. 2814. Infectious substances which cause disease only
in animals shall be assigned to UN No. 2900;
(b) Assignment to UN No. 2814 or UN No. 2900 shall be based on the known medical history and
symptoms of the source human or animal, endemic local conditions, or professional judgement
concerning individual circumstances of the source human or animal.
NOTE 1: The proper shipping name for UN No. 2814 is "INFECTIOUS SUBSTANCE, AFFECTING
HUMANS". The proper shipping name for UN No. 2900 is "INFECTIOUS SUBSTANCE,
AFFECTING ANIMALS only".
NOTE 2: The following table is not exhaustive. Infectious substances, including new or emerging
pathogens, which do not appear in the table but which meet the same criteria shall be assigned to
Category A. In addition, if there is doubt as to whether or not a substance meets the criteria it shall
be included in Category A.
NOTE 3: In the following table, the microorganisms written in italics are bacteria, mycoplasmas,
rickettsia or fungi
INDICATIVE EXAMPLES OF INFECTIOUS SUBSTANCES INCLUDED IN CATEGORY A
IN ANY FORM UNLESS OTHERWISE INDICATED
(2.2.62.1.4.1)
UN Number and
name
Microorganism
UN No. 2814
Infectious
substances affecting
humans
Bacillus anthracis (cultures only)
Brucella abortus (cultures only)
Brucella melitensis (cultures only)
Brucella suis (cultures only)
Burkholderia mallei - Pseudomonas mallei – Glanders (cultures only)
Burkholderia pseudomallei – Pseudomonas pseudomallei (cultures only)
Chlamydia psittaci - avian strains (cultures only)
Clostridium botulinum (cultures only)
Coccidioides immitis (cultures only)
Coxiella burnetii (cultures only)
Crimean-Congo haemorrhagic fever virus
Dengue virus (cultures only)
Eastern equine encephalitis virus (cultures only)
Escherichia coli, verotoxigenic (cultures only) a
Ebola virus
Flexal virus
Francisella tularensis (cultures only)
Guanarito virus
Hantaan virus
Hantavirus causing haemorrhagic fever with renal syndrome
Hendra virus
Hepatitis B virus (cultures only)
Herpes B virus (cultures only)
Human immunodeficiency virus (cultures only)
Highly pathogenic avian influenza virus (cultures only)
Japanese Encephalitis virus (cultures only)
Junin virus
Kyasanur Forest disease virus
Lassa virus
Machupo virus
Marburg virus
Monkeypox virus
Mycobacterium tuberculosis (cultures only) a
Nipah virus
Omsk haemorrhagic fever virus
Poliovirus (cultures only)
Rabies virus (cultures only)
Rickettsia prowazekii (cultures only)
Rickettsia rickettsii (cultures only)
Rift Valley fever virus (cultures only)
Russian spring-summer encephalitis virus (cultures only)
Sabia virus
Shigella dysenteriae type 1 (cultures only) a
Tick-borne encephalitis virus (cultures only)
Variola virus
Venezuelan equine encephalitis virus (cultures only)
West Nile virus (cultures only)
Yellow fever virus (cultures only)
Yersinia pestis (cultures only)
UN No. 2900
Infectious
substances affecting
animals only
African swine fever virus (cultures only)
Avian paramyxovirus Type 1 - Velogenic Newcastle disease virus (cultures only)
Classical swine fever virus (cultures only)
Foot and mouth disease virus (cultures only)
Lumpy skin disease virus (cultures only)
Mycoplasma mycoides - Contagious bovine pleuropneumonia (cultures only)
Peste des petits ruminants virus (cultures only)
Rinderpest virus (cultures only)
Sheep-pox virus (cultures only)
Goatpox virus (cultures only)
Swine vesicular disease virus (cultures only)
Vesicular stomatitis virus (cultures only)
a Nevertheless, when the cultures are intended for diagnostic or clinical purposes, they may be classified as
infectious substances of Category B.

Category B: An infectious substance which does not meet the criteria for inclusion in Category A.
Infectious substances in Category B shall be assigned to UN No. 3373.
NOTE: The proper shipping name of UN No. 3373 is "BIOLOGICAL SUBSTANCE, CATEGORY B ".

Exemptions

Substances which do not contain infectious substances or substances which are unlikely to cause
disease in humans or animals are not subject to the provisions of ADR unless they meet the criteria for
inclusion in another class.

Substances containing microorganisms which are non-pathogenic to humans or animals are not
subject to ADR unless they meet the criteria for inclusion in another class.

Substances in a form that any present pathogens have been neutralized or inactivated such that they no
longer pose a health risk are not subject to ADR unless they meet the criteria for inclusion in another
class.
NOTE: Medical equipment which has been drained of free liquid is deemed to meet the requirements
of this paragraph and is not subject to the provisions of ADR.

Substances where the concentration of pathogens is at a level naturally encountered (including
foodstuff and water samples) and which are not considered to pose a significant risk of infection are
not subject to ADR unless they meet the criteria for inclusion in another class.
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