Chemically unstable substances of Class 6.1 shall not be accepted for carriage unless the necessary precautions have been taken to prevent the possibility of a dangerous decomposition or polymerization under normal conditions of carriage. For the precautions necessary to prevent polymerization, see specialprovision 386 of Chapter 3.3. To this end particular care shall be taken to ensure that receptacles and tanks do not contain any substances liable to promote these reactions.

The following substances and mixtures shall not be accepted for carriage:

-Hydrogen cyanide, anhydrous or in solution, which do not meet the descriptions ofUNNos.1051, 1613, 1614 and 3294;

-metal carbonyls, having a flash-point below 23 °C, other than UN Nos. 1259 NICKELCARBONYL and 1994 IRON PENTACARBONYL;

-2,3,7,8-TETRACHLORODIBENZO-P-DIOXINE (TCDD) in concentrations consideredhighly toxic in accordance with the criteria in 2.2.61.1.7;

-UN No. 2249 DICHLORODIMETHYL ETHER, SYMMETRICAL;

-Preparationsof phosphides without additives inhibiting the emission of toxic flammable gases.

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3   Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directive 67/548/EEC and 1999/45/EC; and amending Regulation (EC) No 1907/2006, published in the Official Journal of the European Union, L 353, 31 December 2008, p 1-1355.

List of collective entries

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a Substances and preparations containing alkaloids or nicotine used as pesticides shall be classified under UN No. 2588 PESTICIDES, SOLID, TOXIC, N.O.S., UNNo.2902 PESTICIDES, LIQUID, TOXIC, N.O.S. or UN No. 2903 PESTICIDES, LIQUID, TOXIC, FLAMMABLE, N.O.S.

b Active substances and triturations or mixtures of substances intended for laboratories and experiments and for the manufacture of pharmaceutical products with other substances shall be classified according to their toxicity (see 2.2.61.1.7 to 2.2.61.1.11).

c Self-heating substances, slightly toxic and spontaneously combustible organometallic compounds, are substances of Class 4.2.

d Water-reactive substances, slightly toxic, and water-reactive organometallic compounds, are substances of Class 4.3.

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e Mercury fulminate, wetted with not less than 20% water, or mixture of alcohol and water by mass is a substance of Class 1, UN No. 0135.

f Ferricyanides, ferrocyanides, alkaline thiocyanates and ammonium thiocyanates are not subject to the provisions of ADR.

g Lead salts and lead pigments which, when mixed in a ratio of 1:1,000 with 0.07M hydrochloric acid and stirred for one hour at a temperature of 23 °C ± 2 °C, exhibit a solubility of 5% or less, are not subject to the provisions of ADR.

h Articles impregnated with this pesticide, such as fibreboard plates, paper strips, cotton-wool balls, sheets of plastics material, in hermetically closed wrappings, are not subject to the provisions of ADR.

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h Articles impregnated with this pesticide, such as fibreboard plates, paper strips, cotton-wool balls, sheets of plastics material, in hermetically closed wrappings, are not subject to the provisions of ADR.

i Mixtures of solids which are not subject to the provisions of ADR and of toxic liquids may be carried underUN No. 3243 without first applying the classification criteria of Class 6.1, provided there is no free liquid visible at the timethe substance is loaded or at the time the packaging, container or transport unit is closed. Each packaging shall correspond to a design type that has passed a leakproofness test at the packing group II level. This entry shall not be used for solids containing a packing group I liquid.

j Highly toxic and toxic flammable liquids having a flash-point below 23 °C are substances of Class 3 except those which are highly toxic by inhalation, as defined in 2.2.61.1.4 to 2.2.61.1.9. Liquids which are highly toxic by inhalation are indicated as "toxic by inhalation" in their proper shipping name in Column (2) or by special provision 354in Column (6) of Table A of Chapter 3.2.

k Flammable liquids, slightly toxic, with the exception of substances and preparations used as pesticides, having a flash-point between 23 °C and 60 °C inclusive, are substances of Class 3.


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c Self-heating substances, slightly toxic and spontaneously combustible organometallic compounds, are substances of Class 4.2.

d Water-reactive substances, slightly toxic, and water-reactive organometallic compounds, are substances of Class 4.3.

l Oxidizing substances, slightly toxic, are substances of Class 5.1.

m Substances slightly toxic and slightly corrosive, are substances of Class 8.

n Metal phosphides assigned to UN Nos. 1360, 1397, 1432, 1714, 2011 and 2013 are substances of Class4.3.

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m Substances slightly toxic and slightly corrosive, are substances of Class 8.

Class 6.2 Infectious substances

Criteria

The heading of Class 6.2 covers infectious substances. For the purposes of ADR, infectious substancesare substances which are known or are reasonably expected to contain pathogens. Pathogens are defined as microorganisms (including bacteria, viruses, rickettsiae, parasites, fungi) and other agents such as prions, which can cause disease in humans or animals.

NOTE 1:Genetically modified microorganisms and organisms, biological products, diagnostic specimens and intentionally infected live animals shall be assigned to this Class if they meet the conditions for this Class.

The carriage of unintentionally or naturally infected live animals is subject only to the relevant rules and regulations of the respectivecountries of origin, transit and destination.

NOTE 2:Toxins from plant, animal or bacterial sources which do not contain any infectious substances or organisms or which are not contained in them are substances of Class 6.1, UNNos. 3172 or 3462.

Substances of Class6.2 are subdivided as follows:

I1 Infectious substances affecting humans;

I2 Infectious substances affecting animals only;

I3 Clinical waste;

I4 Biological substances.

Definitions

For the purposes of ADR,

"Biological products" are those products derived from living organisms which are manufactured and distributed in accordance with the requirements of appropriate national authorities, which may have special licensing requirements, and are used either for prevention, treatment, or diagnosis of disease in humans or animals, or for development, experimental or investigational purposes related thereto. They include, but are not limited to, finished or unfinished products such as vaccines;

"Cultures"are the result of aprocess by which pathogens are intentionally propagated. This definition does not include human or animal patient specimens as defined in this paragraph;

"Medical or clinical wastes" are wastes derived from the medical treatment of animals or humans or from bio-research;

"Patient specimens"are thosecollected directly from humans or animals, including, but not limited to, excreta, secreta, blood and its components, tissue and tissue fluid swabs, and body parts being carried for purposes such as research,diagnosis, investigational activities, disease treatment and prevention.

Classification

Infectious substances shall be classified in Class 6.2 and assigned to UNNos. 2814, 2900, 3291 or 3373, as appropriate.Infectious substances are divided into the following categories:

Category A: An infectious substance which is carried in a form that, when exposure to it occurs, is capable of causing permanent disability, life-threatening or fatal disease in otherwise healthy humans or animals. Indicative examples of substances that meet these criteria are given in the table in this paragraph.

NOTE: An exposure occurs when an infectious substance is released outside of the protective packaging, resulting in physical contact with humans or animals.

(a) Infectious substances meeting these criteria which cause disease in humans or both in humansand animals shall be assigned to UN No. 2814. Infectious substances which cause disease onlyin animals shall be assigned to UN No.2900;

(b) Assignment to UN No. 2814 or UN No. 2900 shall be based on the known medical history andsymptoms of the source human or animal, endemic local conditions, or professional judgementconcerning individual circumstances of the source human or animal.

NOTE 1:The proper shipping name for UN No. 2814 is "INFECTIOUS SUBSTANCE, AFFECTING HUMANS". The proper shipping name for UN No. 2900 is "INFECTIOUS SUBSTANCE, AFFECTING ANIMALS only".

NOTE 2:The following table is not exhaustive. Infectious substances, including new or emerging pathogens, which do not appear in the table but which meet the samecriteria shall be assigned to Category A. In addition, if there is doubt as to whether or not a substance meets the criteria it shall be included in CategoryA.

NOTE 3: In the following table, the microorganisms written in italics are bacteria, mycoplasmas, rickettsia or fungi.

 

INDICATIVE EXAMPLES OF INFECTIOUS SUBSTANCES INCLUDED IN CATEGORY A IN ANY FORM UNLESS OTHERWISE INDICATED

(2.2.62.1.4.1)

UN Number and name

Microorganism

UN No. 2814

Infectious substances affecting humans

Bacillus anthracis (cultures only) Brucella abortus (cultures only) Brucella melitensis (cultures only) Brucella suis (cultures only)

Burkholderia mallei - Pseudomonas mallei – Glanders (cultures only) Burkholderia pseudomallei – Pseudomonas pseudomallei (cultures only) Chlamydia psittaci - avian strains (cultures only)

Clostridium botulinum (cultures only)

Coccidioides immitis (cultures only) Coxiella burnetii (cultures only)

Crimean-Congo haemorrhagic fever virus Dengue virus (cultures only)

Eastern equine encephalitis virus (cultures only) Escherichia coli, verotoxigenic (cultures only) a Ebola virus

Flexal virus

Francisella tularensis (cultures only)

Guanarito virus Hantaan virus

Hantavirus causing haemorrhagic fever with renal syndrome Hendra virus

Hepatitis B virus (cultures only) Herpes B virus (cultures only)

Human immunodeficiency virus (cultures only)

Highly pathogenic avian influenza virus (cultures only) Japanese Encephalitis virus (cultures only)

Junin virus

Kyasanur Forest disease virus Lassa virus

Machupo virus Marburg virus

 

Monkeypox virus

Mycobacterium tuberculosis (cultures only) a

Nipah virus

Omsk haemorrhagic fever virus Poliovirus (cultures only) Rabies virus (cultures only)

Rickettsia prowazekii (cultures only) Rickettsia rickettsii (cultures only) Rift Valley fever virus (cultures only)

Russian spring-summer encephalitis virus (cultures only) Sabia virus

Shigella dysenteriae type 1 (cultures only) a Tick-borne encephalitis virus (cultures only) Variola virus

Venezuelan equine encephalitis virus (cultures only) West Nile virus (cultures only)

Yellow fever virus (cultures only)

Yersinia pestis (cultures only)

 

 

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a  Nevertheless, when the cultures are intended for diagnostic or clinical purposes, they may be classified as infectious substances of Category B.

 

INDICATIVE EXAMPLES OF INFECTIOUS SUBSTANCES INCLUDED IN CATEGORY A

IN ANY FORM UNLESS OTHERWISE INDICATED (2.2.62.1.4.1)

UN Number and name

Microorganism

UN No. 2900

African swine fever virus (cultures only)

Infectious

Avian paramyxovirus Type 1 - Velogenic Newcastle disease virus (cultures only)

substances affecting animals only

Classical swine fever virus (cultures only) Foot and mouth disease virus (cultures only)

 

Lumpy skin disease virus (cultures only)

 

Mycoplasma mycoides - Contagious bovine pleuropneumonia (cultures only)

 

Peste des petits ruminants virus (cultures only)

 

Rinderpest virus (cultures only)

 

Sheep-pox virus (cultures only)

 

Goatpox virus (cultures only)

 

Swine vesicular disease virus (cultures only)

 

Vesicular stomatitis virus (cultures only)

Category B: An infectious substance which does not meet the criteria for inclusion in CategoryA. Infectious substances in Category B shall be assigned to UN No. 3373.

NOTE:The proper shipping name of UN No. 3373 is "BIOLOGICAL SUBSTANCE, CATEGORY B".

Exemptions

Substances which do not contain infectious substances or substances which are unlikely to cause disease in humans or animals are not subject to the provisions of ADR unless they meet the criteria for inclusion in another class.

Substances containing microorganisms which are non-pathogenic to humans or animals are not subject to ADR unless they meet the criteria for inclusion in another class.

Substances in a form that any present pathogens have been neutralized or inactivated such that they no longer pose a health risk are not subject to ADR unless they meet the criteria for inclusion in another class.

NOTE:Medical equipment which has been drained of free liquid is deemed to meet the requirements of this paragraph and is not subject to the provisions of ADR.

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