If a mixture contains only one active substance, and the LD50 of that constituent is known, in the absence of reliable acute oral and dermal toxicity data on the actual mixture to be carried, the oral or dermal LD50 may be obtained by the following method:

If a mixture contains more than one active constituent, there are three possible approaches that may be used to determine the oral or dermal LD50 of the mixture. The preferred method is to obtain reliable acute oral and dermal toxicity data on the actual mixture to be carried. Ifreliable, accuratedata are not available, then either of the following methods may be performed:

(a) Classify the formulation according to the most hazardous constituent of the mixture as if thatconstituent were present in the same concentration as the total concentration of all activeconstituents; or

b) Apply the formula:

where:

C = the percentage concentration of constituent A, B, ..., Z in the mixture;

T = the oral LD50values of constituent A, B, ...Z;

TM = the oral LD50value of the mixture.

NOTE: This formula can also be used for dermal toxicities provided that this information is available on the same species for all constituents. The use of this formula does not take into account any potentiation or protective phenomena.

If the oral or dermal LD50value for a pesticide preparation is not known, but the LD50value of its active substance(s) is known, the LD50value for the preparation may be obtained by applying the procedures in 2.2.61.1.10.

NOTE : LD50 toxicity data for a number of common pesticides may be obtained from the most current edition of the document "The WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification" available from the International Programme on Chemical Safety, World Health Organisation (WHO), 1211Geneva 27, Switzerland. While that document may be used as a source of LD50 data for pesticides, its classification system shall not be used for purposes of transport classification of, or assignment of packing groups to, pesticides, which shall be in accordance with the requirements of ADR.

The proper shipping name used in the carriage of the pesticide shall be selected on the basis of the active ingredient, of the physical state of the pesticide and any subsidiary hazardsit may exhibit (see 3.1.2).

If substances of Class 6.1, as a result of admixtures, come into categories of hazarddifferent from those to which the substances mentioned by name in Table A of Chapter 3.2 belong, these mixtures or solutions shall be assigned to the entries to which they belong on the basis of their actual degree of danger.

NOTE: For the classification of solutions and mixtures (such as preparations and wastes), see also2.1.3.

On the basis of the criteria of 2.2.61.1.6 to 2.2.61.1.11, it may also be determined whether the nature of a solution or mixture mentioned by name or containing a substance mentioned by name is such that the solution or mixture is not subject to the requirements for this Class.

Substances, solutions and mixtures, with the exception of substances and preparations used as pesticides, which are not classified as acute toxic category 1, 2 or 3 according to Regulation (EC) No 1272/20083, may be considered as substances not belonging to class 6.1.

Chemically unstable substances of Class 6.1 shall not be accepted for carriage unless the necessary precautions have been taken to prevent the possibility of a dangerous decomposition or polymerization under normal conditions of carriage. For the precautions necessary to prevent polymerization, see specialprovision 386 of Chapter 3.3. To this end particular care shall be taken to ensure that receptacles and tanks do not contain any substances liable to promote these reactions.

The following substances and mixtures shall not be accepted for carriage:

-Hydrogen cyanide, anhydrous or in solution, which do not meet the descriptions ofUNNos.1051, 1613, 1614 and 3294;

-metal carbonyls, having a flash-point below 23 °C, other than UN Nos. 1259 NICKELCARBONYL and 1994 IRON PENTACARBONYL;

-2,3,7,8-TETRACHLORODIBENZO-P-DIOXINE (TCDD) in concentrations consideredhighly toxic in accordance with the criteria in 2.2.61.1.7;

-UN No. 2249 DICHLORODIMETHYL ETHER, SYMMETRICAL;

-Preparationsof phosphides without additives inhibiting the emission of toxic flammable gases.

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3   Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directive 67/548/EEC and 1999/45/EC; and amending Regulation (EC) No 1907/2006, published in the Official Journal of the European Union, L 353, 31 December 2008, p 1-1355.

The heading of Class 6.2 covers infectious substances. For the purposes of ADR, infectious substancesare substances which are known or are reasonably expected to contain pathogens. Pathogens are defined as microorganisms (including bacteria, viruses, rickettsiae, parasites, fungi) and other agents such as prions, which can cause disease in humans or animals.

NOTE 1:Genetically modified microorganisms and organisms, biological products, diagnostic specimens and intentionally infected live animals shall be assigned to this Class if they meet the conditions for this Class.

The carriage of unintentionally or naturally infected live animals is subject only to the relevant rules and regulations of the respectivecountries of origin, transit and destination.

NOTE 2:Toxins from plant, animal or bacterial sources which do not contain any infectious substances or organisms or which are not contained in them are substances of Class 6.1, UNNos. 3172 or 3462.